Characterization Methods of Amorphous Form Stability in Solid Dispersion : A Review
نویسندگان
چکیده
منابع مشابه
Solubility enhancement of glimperide: Development of solid dispersion by solvent melt method, characterization and dosage form development
The aim of the present work was to develop immediate release dosage form of the solid dispersion of glimperide (GLIM) for potential enhancement in the bioavailability. The solid dispersions of GLIM were prepared with PEG6000, PVP K30 and Poloxamer 188, in 1:1, 1:3 and 1:5 %w/w ratio by using solvent wetting and solvent melt method. The in vitro dissolution parameters (%DE10min, %DE30min, %DE60m...
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Epigallocatechin gallate (EGCG) has been recognized as the most prominent green tea extract due to its healthy influences. The high instability and low bioavailability, however, strongly limit its utilization in food and drug industries. This work, for the first time, develops amorphous solid dispersion of EGCG to enhance its bioavailability and physical stability. Four commonly used polymeric ...
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Administered by an oral route, Furosemide (FUR), a diuretic used in several edematous states and hypertension, presents bioavailability problems, reported as a consequence of an erratic gastrointestinal absorption due to various existing polymorphic forms and low and pH-dependent solubility. A mucoadhesive sublingual fast-dissolving FUR based film has been developed and evaluated in order to op...
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ژورنال
عنوان ژورنال: Indonesian Journal of Pharmaceutics
سال: 2020
ISSN: 2597-8748
DOI: 10.24198/idjp.v2i2.27123